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When seeing a deal in your city, you should not automatically accept or decline it - sometimes they are good but they can also be very good as well. When you see a deal popping up, calculate how much it will reward you per item and then click somewhere OUTSIDE the screen (NOT "No" or Yes") and go to the Depot. There you can see how much this or these items cost there and see if that's a good or a bad deal. In case you will get more from the deal than from the Depot, you should take the deal or even might consider buying the missing items from the shop to make a fast and easy profit!
Use every single space in your city layout to build parks and specialization because this will give you additional citizen which will result in more money you will earn without doing anything
The Airport and the Cargo Ship Dock will show you frequent orders that will reward you with keys - these keys are extremely valuable for specializations and special obstacles that will boost your citizens and return tons of more simoleons for you (see #2)